Several high-profile figures have shared their personal experiences with weight-loss medications such as Ozempic and Mounjaro, offering insights into the potential benefits and drawbacks of these treatments. These drugs, originally developed to manage type 2 diabetes, have gained popularity for their appetite-suppressing effects and significant weight loss outcomes.

Sharon Osbourne, 73, disclosed that she used Ozempic in 2023 and lost 3 stone (approximately 42 pounds) over four months. However, she reported enduring persistent nausea and warned others after experiencing unintended excessive weight loss, stating that she felt “too skinny” and unable to regain the lost weight.

Lottie Moss, 28, half-sister of model Kate Moss, described a severe adverse reaction after taking Ozempic in 2024. Despite her relatively low body weight—less than 8 stone (around 112 pounds)—she suffered dehydration and a seizure, leading to hospitalization. She cautioned others against using the drug, emphasizing the severity of her experience.

Stephen Fry, 69, who began using Ozempic in the United States, praised the medication for effectively reducing his appetite for both food and alcohol. He reportedly lost 5.5 stone (approximately 77 pounds) but also faced severe side effects, including intense nausea that caused him to vomit up to five times daily.

James Corden, 48, experimented with Ozempic in 2024 but found it largely ineffective for his needs. While acknowledging the drug’s capacity to suppress hunger, he noted it did not address emotional or psychological aspects of eating and described his eating habits as unrelated to physical hunger.

Gemma Collins, 45, who has been open about her plus-size figure, used the weight-loss drug Mounjaro in 2024 and lost over 3.5 stone (about 49 pounds). She later stopped the medication due to concerns about rapid facial ageing and the development of gallstones, a painful side effect associated with the treatment.

Boy George, 65, detailed in his 2024 memoir “Karma” his use of both Ozempic and Mounjaro. He stated that these drugs helped him gain control over his appetite, expressing a belief that many individuals experiencing rapid weight loss are using these medications.

Robbie Williams, 52, has publicly supported the use of fat-loss injections but voiced concerns over potential eye problems he associates with Mounjaro. He described worsening blurry vision and fears of losing sight, yet said he intends to continue the treatment despite these issues, citing his commitment to the drug’s effects.

These candid accounts from celebrities highlight a range of experiences with GLP-1 receptor agonists, showing both their weight loss potential and the significant side effects that can accompany their use. Medical experts caution that while these medications can be effective, they should be used under close supervision due to risks including nausea, gallstones, and possible impacts on vision.