City of Hope reported $5.9 billion in revenue for the fiscal year ending September 30, 2025, driven by a combination of patient care, research grants, contributions, and other sources, according to data from the California Department of Health Care Access and Information. The comprehensive revenue reflects the organization’s expanding footprint and broadening range of activities in cancer treatment and research.
Originally a single-campus institution in Duarte, California, City of Hope has evolved into a national healthcare network following its 2022 acquisition of Cancer Treatment Centers of America. This transaction significantly expanded City of Hope’s presence across multiple states and demonstrated how a nonprofit healthcare system can pursue growth strategies commonly associated with for-profit entities, without compromising its clinical and research missions.
The organization's growth accelerated with the December 1, 2025, opening of a new $1.5 billion, 73-bed hospital in Orange County. This facility houses more than 100 specialized oncologists, including surgical, medical, and hematology experts focusing on cancers of the thoracic, gastrointestinal, urologic, and blood systems, as well as women’s cancers. The hospital plays a critical role for patients enrolled in early-phase clinical trials, who require close monitoring in clinical settings.
Annette Walker, president of City of Hope Orange County, emphasized the community-driven nature of the project, acknowledging philanthropic partners, staff, physicians, and local residents who contributed to making the new hospital a reality.
Philanthropic support has been instrumental in City of Hope’s expansion and innovation efforts. In 2023, Andrew and Peggy Cherng, co-founders of Panda Express, pledged $100 million through their family foundation to establish the Cherng Family Center for Integrative Oncology. This gift matched the largest individual donation in the institution’s history. Previously, renowned geneticist Dr. Arthur Riggs donated $100 million in 2021 before his passing from blood cancer. In 2024, entrepreneur Emmet Stephenson Jr. and his daughter Tessa committed $150 million following the loss of his wife to pancreatic cancer. Part of this funding supports an annual $1 million prize awarded to scientists advancing pancreatic cancer research.
The organization’s annual Music, Film and Entertainment Industry Spirit of Life Gala, scheduled for October 27, 2026, at the Pacific Design Center, is a key fundraiser. This year’s event will honor music executive Larry Mestel, founder and CEO of Primary Wave, with proceeds supporting City of Hope’s work on CAR T cell therapy, other cellular immunotherapies, and breast cancer research initiatives. The gala’s performers will include Melissa Etheridge, Stevie Nicks, and Jackson Browne. Etheridge, a breast cancer survivor and advocate, highlighted the personal significance of the event, underscoring the importance of research and compassionate care.
Looking forward, City of Hope aims to enhance cancer care through technological advancements, including decentralized treatment delivery via outpatient clinics and remote monitoring. The use of chimeric antigen receptor (CAR) T cell therapies is expected to become more common, potentially reducing hospital stays by 60%, improving outcomes, and lowering costs.
Artificial intelligence (AI) is also central to City of Hope’s strategy. The organization is developing AI tools to analyze extensive clinical and genomic data, accelerating progress in precision medicine by improving patient-trial matching and drug development. AI-guided robotic surgical systems are being utilized to increase procedural accuracy, reduce complications, and shorten recovery times.
“We expect AI to transform many aspects of cancer treatment—from faster drug discovery to enhanced diagnostics and improved patient experiences,” said a City of Hope spokesperson, highlighting the technology’s broad impact on healthcare delivery.