Jon Holmes, the BAFTA-winning comedy writer and co-creator of Radio 4’s Dead Ringers, was diagnosed with prostate cancer in 2023 at the age of 54. Following his diagnosis, he underwent robot-assisted surgery to remove his prostate, a decision made after early detection through a PSA (prostate-specific antigen) test. Three years later and currently cancer-free, Holmes continues to navigate the complexities of the disease and is actively raising awareness around prostate cancer through his work.

Holmes admits that prior to his diagnosis, he had limited understanding of the prostate gland and the factors surrounding prostate cancer, a gap in knowledge that he believes is common among men. He recalls initially being unaware of what the prostate was or its function, and describes the learning process since treatment as “a steep learning curve.” He has since taken steps to demystify the disease and encourage open conversations about men's health, which he says are often avoided in informal settings such as pubs, where discussions of sexual or urinary health are typically taboo.

To address these issues, Holmes has launched a quiz-style podcast series, “The Big Mind the Gap,” developed in collaboration with GenesisCare UK, a private cancer treatment provider. The podcast blends humor with expert insights, featuring interviews with clinicians and patient stories to highlight treatment options, the risk of cancer recurrence, and the reality of living beyond diagnosis. Holmes emphasizes that prostate cancer can return even after prostate removal—a fact he learned only after surgery—due to residual cells left behind following treatment. PSA testing remains critical post-surgery, with follow-up intervals that typically extend from every three months to annually.

Research cited by GenesisCare UK indicates that many men remain poorly informed about prostate cancer treatment options, with nearly half (47%) reporting insufficient knowledge. Factors contributing to this include feelings of being overwhelmed, fear, embarrassment, and confusion regarding medical guidance. Additionally, studies show that recurrence rates after prostatectomy range from 16 to 46 percent, underscoring the importance of ongoing surveillance and education.

Experts featured on the podcast, including consultant clinical oncologists, stress the need for patients to explore treatment options carefully. Newer therapies, such as MRI-guided stereotactic ablative radiotherapy (SABR), offer promising outcomes with high rates of cancer control and better preservation of quality of life, particularly concerning sexual function. These advances provide alternatives to surgery for some patients, highlighting the importance of personalized treatment planning.

Holmes also points out that routine PSA screening is not standard practice in the UK, with general practitioners typically testing only symptomatic individuals or those with a family history. His own cancer was detected after a chance inquiry about family medical history prompted his GP to perform a PSA test, a moment Holmes believes saved his life.

Through his podcasts and public engagement, Holmes aims to empower men to be proactive about prostate cancer testing and treatment discussions. He encourages men, particularly those over 50 (or over 45 for Black men, who are at higher risk), to seek testing even in the absence of symptoms, ask questions, and openly discuss their experiences. Holmes hopes to break the stigma around men's health issues, using humor and candid conversation to foster awareness and support for those affected by prostate cancer.