The annual Comics Come Home festival is approaching its 30th anniversary, with this year’s event set for November 7 at 8 p.m. at TD Garden, located at 100 Legends Way in Boston. Tickets start at $93.65, and the show promises a lineup of prominent comedians, along with a few musical surprises, according to co-founder Denis Leary.

Leary, 69, expressed enthusiasm for the event during a recent interview, calling the roster “killer” and highlighting the presence of several headline performers. Among those returning is Steve Stewart, who participated in the inaugural Comics Come Home in 1995 at the Orpheum Theatre, despite performing while ill with food poisoning. Leary recalled Stewart’s determination to complete his set, even while battling sickness backstage. Actor and comedian Steve Romano, a Worcester native and fellow cast member of the upcoming “Ice Age” sequel “Ice Age: Boiling Point,” is also making a return appearance.

The first Comics Come Home show featured notable acts such as Janeane Garofalo, Steven Wright, Steve Sweeney, Don Gavin, and special appearances by Michael J. Fox and Mike Myers via satellite. Co-founder Cam Neely, now 61, commended Leary for assembling star-studded lineups over the years, saying the quality of talent is a key factor in the festival’s enduring success.

Memorable moments over the festival’s history include guest performances by John Mayer in 2017 as a surprise for Jimmy Fallon, and Joe Perry of Aerosmith, who joined Leary for a live rendition of a popular song. Leary also recounted the excitement of comedians Sebastian Maniscalco and Conan O’Brien during a visit to the Bruins locker room, highlighting the event’s connection to local culture and sports.

In addition to showcasing established comedians, Comics Come Home places a strong emphasis on giving emerging and local comedians their first major platform, with rising talent such as Zarna Garg making her debut at the 2024 show. Leary underscored the importance of this opportunity for new performers to play in front of large audiences at a prestigious venue.

The festival benefits the Cam Neely Foundation, which supports cancer patients and their families. Leary noted the foundation’s impact, including personal connections with performers’ families, like Jimmy Fallon’s father, who received care at the Neely House at Tufts Medical Center.

Neely reflected on the growth of Comics Come Home since moving to Boston in 1986 and the challenge of securing TD Garden as a venue. He initially doubted the ability to sell out the arena but said the event has consistently succeeded in doing so. Looking ahead, both Leary and Neely plan to continue the festival for the foreseeable future and hope to eventually pass its stewardship to a younger generation of Boston-area comedians.

The event remains a fixture in Boston’s entertainment calendar, blending comedic talent with charitable goals and local pride.