The Strokes returned to Boston for the first time in two decades with a performance at TD Garden on Tuesday night, delivering a nearly two-hour set that blended new material with long-standing fan favorites. The New York City band, which rose to fame in the early 2000s, showcased tracks from their upcoming album, "Reality Awaits," slated for release next month, alongside selections from their Grammy-winning 2020 album, "The New Abnormal," and earlier hits.

Guest musician Steve Schiltz filled in on guitar for founding member Nick Valensi, who recently announced a break from touring. The band opened with songs including “falling Out of Love” and “going Shopping,” the latter noted for its precise rhythms and interlocking guitar work. The set also featured energetic performances of classics such as “Take It or Leave It” and “Last Nite,” as well as newer tracks like “The Adults Are Talking,” which highlighted a softer side of the group’s signature sound.

Supporting the Strokes were two opening acts that capitalized on their established status. Hamilton Leithauser, former frontman of The Walkmen and a fellow New York indie scene alumnus with ties to Boston University, performed a concise set including his standout song “A 1000 Times.” Leithauser also made a return during the Strokes’ encore, substituting for Casablancas on a cover of The Walkmen’s “Heaven.” The middle act, bassist and singer Thundercat, brought his unique brand of jazz fusion-inflected funk to the stage, showcasing his gold-flaked semi-hollow bass guitar and adding a fresh dynamic to the evening’s lineup.

While the openers benefited from clear sound mixes, some sound issues were reported during the Strokes’ headlining set. Julian Casablancas’s vocals at times struggled to rise above a sharp, tinny instrumental mix. Despite this, Casablancas’s onstage banter included nods to Boston’s local culture, though some remarks, including references to the city’s colleges, were met with mixed reaction.

The performance underscored the band’s enduring ability to craft memorable rock hooks more than 20 years after their breakthrough. For many attendees, who may have first encountered the Strokes as teenagers, the concert was as much a reflection on youth as a celebration of rock music’s continued relevance. The show closed with the band’s 2003 track “What Ever Happened?,” a poignant reminder of their early days and the passage of time in their career.