The National Anti-Vivisection Society (NAVS), headquartered in Chicago, continues its nearly century-long mission to end animal experimentation and promote more effective scientific research methods that do not involve animals. The nonprofit organization advocates for the adoption of innovative technologies such as human cell and tissue models, organ-on-chip systems, and computational approaches, which provide alternatives to traditional animal testing.

NAVS highlights the persistent challenges in drug development, noting that more than 90% of drugs deemed safe in animal studies ultimately fail in human clinical trials due to safety or efficacy issues. This discrepancy underscores the organization’s argument for shifting toward research methods that more accurately reflect human biology, potentially improving both scientific outcomes and animal welfare.

Operating as a 501(c)(3) charitable organization without government funding, NAVS relies primarily on individual donations and partnerships to support its programs. These initiatives focus on advancing humane scientific practices, educating emerging scientists and the public, advocating for policy changes, and assisting animals impacted by research. The organization encourages supporters to contribute through its website or by engaging in advocacy efforts promoting smarter science and stronger protections for animals.

NAVS maintains a national presence, offering resources and support to scientists, educators, students, animal advocates, and sanctuaries across the United States. The group also provides avenues for public involvement through its online advocacy center and maintains active social media channels to foster community engagement.