The New England Patriots face the Buffalo Bills on Sunday at the newly opened Highmark Stadium, seeking to rebound from a disappointing 1-2 start to the season. The Patriots enter the game following a lopsided 35-6 loss to the Jacksonville Jaguars, exposing ongoing struggles on both sides of the ball. Injuries continue to hamper the team, with cornerback Christian Gonzalez and defensive tackle Christian Barmore sidelined. Meanwhile, concerns persist over quarterback Drake Maye’s sudden dip in performance, a troubling development for a player who was the MVP runner-up last season.

Maye has struggled through the first three games of the year, throwing only one touchdown pass against six interceptions, a stark contrast to his previous output of 31 touchdowns to eight interceptions. His decision-making, especially in the red zone, has raised questions, as has a perceived decline in arm strength. While Maye was a standout in his first full NFL season in 2025, his current form suggests he is contending with either physical or mental setbacks, or both, possibly linked to the intense defensive pressure he faced in last postseason.

The Patriots’ offense has also encountered difficulties beyond Maye’s play. Wide receiver Mack Hollins has been the only reliable target, leading the team in receptions and yards, while veteran tight end Hunter Henry remains underutilized, registering only seven catches for 71 yards through three games, far below his career-best season last year. The running game has struggled to convert, frequently forcing the offense into third-and-long situations. This presents a critical challenge for coach Mike Vrabel and offensive coordinator Josh McDaniels as they look for ways to reinvigorate their offense against a potent Bills defense.

Buffalo enters the matchup with a perfect 3-0 record, spearheaded by quarterback Josh Allen’s continued strong performance. Allen has amassed 786 passing yards, five touchdowns, and two interceptions, along with six rushing touchdowns. The Bills also boast a formidable pass rush led by defensive end Greg Rousseau, who has recorded two sacks in each of the team's first three games—an achievement only matched twice in NFL history. Rousseau, who earned AFC Defensive Player of the Month honors for September, poses a significant threat to New England’s struggling offensive line.

Running back James Cook is another key player for the Bills, currently showcasing an outstanding season with 346 rushing yards and two touchdowns, averaging six yards per carry. With the absence of Barmore on the Patriots’ defensive front, Cook’s impact may prove even more pronounced.

As the Patriots seek to regain momentum, many will recall last season’s pivotal Week 5 victory over Buffalo, a 23-20 game that launched New England’s run to Super Bowl LX. However, replicating that success will require a notable turnaround in Maye’s play and improvements across the offense. Given Buffalo’s high-scoring offense and the Patriots’ current struggles, the Bills appear favored to emerge with a convincing victory Sunday.