Bryan Johnson, a centimillionaire biohacker known for his extensive longevity experiments, has recently claimed to have “cloned” himself by reprogramming stem cells to create new versions of his own cells in a laboratory setting. This development marks a shift in his pursuit of extending human life, which began with efforts to restore his body to a youthful state and now aims at generating replacement organs outside the body.
Johnson first came to public attention in late 2023 following a viral keynote address at a psychedelics and longevity conference, where he participated remotely due to a biometric-monitoring algorithm that discouraged disruptive travel. He emphasized the disruptive effects of travel on sleep and diet, underscoring his reliance on continuous health monitoring to guide his lifestyle choices.
The entrepreneur made his fortune with the 2013 sale of Braintree, a payment services company that included the popular app Venmo. Since then, he has invested approximately $2 million per year in an intensive longevity regimen, which he brands as “Project Blueprint.” This routine gained wide media exposure in early 2023, describing his rigorous daily regimen of early wake-ups, multiple skin treatments, specialized diets, and constant medical testing such as stool analysis.
One of the more unusual aspects of his protocol included receiving plasma transfusions from his 17-year-old son, a practice he referenced humorously to counter media portrayals. Despite the high-profile nature of his experiments, he has commercialized some elements of his program, offering branded health supplements and skincare products for sale to consumers.
Johnson’s interest in longevity followed a personal transformation after selling Braintree. He described himself at the time as overweight and depressed, with an unhealthy diet heavy in sugar. Leaving behind an unhappy marriage and the Mormon faith in which he was raised, he began implementing strict health measures such as a 20-hour daily fasting window and reliance on hundreds of biomarkers to guide his lifestyle, reducing impulsive behaviors and placing his health decisions under algorithmic control. He claims these measures have rejuvenated his body to function similarly to that of an 18-year-old, although his avoidance of sunlight has affected his appearance.
In recent years, Johnson has incorporated psychedelics into his regimen, viewing them as potential tools to enhance longevity. In 2025, coinciding with political shifts in the United States, he publicly supported Donald Trump’s 2024 election victory and expressed optimism about America’s future health and vitality. At the 2023 conference, he briefly mentioned using intravenous ketamine related to neuroimaging experiments for his company Kernel. In late 2025, he consumed a high dose of psilocybin mushrooms during a livestream to explore their effects on longevity.
Johnson’s evolving biohacking efforts reflect a blend of cutting-edge science, personal experimentation, and commercial ventures, positioning him as a prominent figure in the growing longevity movement.