This week’s lineup of National Football League (NFL) and college football games across the United States features a mix of notable matchups, point spreads, and over/under totals, with one NFL game scheduled internationally in London, England.

In the NFL, the Seattle Seahawks enter Thursday’s opener favored by 2.5 points over the Denver Broncos, with a projected combined score of 40.5 points. Other Thursday matchups include the New Orleans Saints, favored by 1.5 points against the New York Giants in a 45.5-point total, and the New England Patriots, who are set as 7.5-point favorites hosting the New York Jets in a contest anticipated to reach 43.5 points.

Friday sees the Jacksonville Jaguars favored by 2.5 points over the Houston Texans in a 42.5-point game. The Baltimore Ravens are favored by 4.5 points against the Cleveland Browns in a lower-scoring game with an over/under of 41.5 points. Indianapolis Colts are projected as 7-point favorites over the Tennessee Titans, with a total points line of 44.

Saturday’s schedule includes the Pittsburgh Steelers as 2.5-point favorites over the Tampa Bay Buccaneers with an over/under of 40.5, and the Philadelphia Eagles favored by 1.5 points against the Carolina Panthers with a 40.5 combined score total. The Chicago Bears hold a 3-point spread at home against the Atlanta Falcons, with a higher over/under of 49.5 points.

One of the more significant spreads appears in the Los Angeles Rams’ matchup against the Arizona Cardinals, with the Rams favored by 12.5 points and an expected 52.5 total points. The Buffalo Bills take a 5.5-point lead over the Las Vegas Raiders in a contest projected to produce 53.5 combined points. The Kansas City Chiefs are favored by 8.5 points against the Los Angeles Chargers, with a relatively lower total of 42.5 points expected in this clash.

Other notable games include the Green Bay Packers favored by 1.5 points against the Dallas Cowboys in what is projected as a high-scoring affair with a 53.5-point total, and the San Francisco 49ers favored by 7.5 points over the Washington Commanders in the NFL’s London game, with an anticipated 50.5 combined score.

In the college football realm, several midweek and weekend games stand out. On Wednesday, Kennesaw State is favored by 3 points against Missouri State with a total of 52.5, while Western Kentucky leads by 1.5 points over Sam Houston, with a higher over/under of 53.5 points.

Thursday features Georgia Southern favored by 3.5 points over Old Dominion in a game with a 47.5 projected total, while East Carolina is a 4.5-point favorite against UAB.

Friday’s lineups include Memphis favored by 7 points at Tulane with an over/under of 55.5, and Purdue as a 3.5-point favorite facing Washington in a 52.5-point game.

Saturday showcases a number of significant matchups featuring top teams and notable spreads. SMU holds a 9.5-point advantage over Virginia, Northwestern is favored by 7.5 points at Michigan State, and Army enters as a 2.5-point favorite over Florida Atlantic.

Some of the more lopsided lines include Clemson’s substantial 41.5-point favoring over Charleston Southern in a 56.5 total, Georgia’s 20.5-point edge against Auburn in a 49.5-point game, and LSU’s 14-point spread over Mississippi State in a matchup expected to yield 58.5 points.

Other key contests include Michigan favored by 6.5 points against Penn State, Alabama favored by 8.5 points over Tennessee, and Texas Tech favored by 14.5 points at Arizona State.

Throughout the weekend, a broad range of contests across different conferences and divisions will take place, offering varied betting lines and expectations for scoring, reflecting the diverse competitive landscape in college football this season.